Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.
This podcast features Jari Laukkanen, M.D., Ph.D., a cardiologist and scientist at the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio. Dr. Laukkanen has been conducting long-term trials looking at the health effects of sauna use in a population of over 2,000 middle-aged men in Finland. The results? Massive reductions in mortality and memory disease in a dose-response fashion at 20-year follow-up.
In this almost 25-minute episode, we talk about...
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Dr. Judith Campisi is a professor of biogerentology at the Buck Institute for Research on Aging and a co-editor in chief of the Aging Journal.
As an expert on cellular senescence, the discussion involves a lot of talk about aging and cancer, where senescence plays a very important fundamental role. What are some of the strategies we might use in the future to prevent senescent cells? What causes them in the first place?
In this 1-hour long conversation, we discuss a great number of very interesting things including:
Studies mentioned: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
Learn more about Dr. Judy Campisi.
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Dr. Gordon Lithgow of the Buck Institute for Research on Aging tells us about worms! Well, more accurately, his lab does research on nematodes, particularly an animal known as C. elegans.
This unassuming scientific model has a lot of important advantages for science: they can be frozen and subsequently thawed and retain viability, they are extremely well understood down to the precise number of cells in their body and the wiring of their nervous system, known as the connectome. Additionally, they have a short lifespan and are cheap to work with. Why would that be advantageous, you may ask?
This is where Dr. Lithgow's work on the Caenorhabditis Intervention Testing Program comes in. Short-lived organisms give Dr. Lithgow and his colleagues the opportunity to see how their biology responds to compounds in different contexts and to do so cheaply and rapidly. Think a vitamin, pharmaceutical or one of any number of other compounds may have a broad effect on longevity? Try it on Caenorhabditis first! Taking this approach allows the broad screening of compounds that might not otherwise get its chance in the limelight if science were limited to only working with rodents, for example.
But what could nematodes possibly have in common with us? The answer to the question is... gene homology! In fact, around 35% of C. elegans genes have a corresponding human version.
In this over 40-minute long conversation with professor Dr. Gordon Lithgow, we talk about...
Learn more about Dr. Gordon Lithgow.
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Click here to visit our crowdsponsor page where you can learn more about how you can support the podcast for as little or as much as you like.
Have you done a 23andMe genetic test?
You can learn more about whether you have some of the specific polymorphisms discussed in this podcast, including ones related to the hemochromatosis and transferrin genes, by clicking here.
If you're anything like me, having the facts straight can sometimes help you to push through the tough part of building new habits or breaking old bad ones. This podcast talks about the realities about what the science says surrounding the consumption of refined sugar.
Some of the facts may surprise you! We talk about the relationship of consumption of refined sugar with...
... and, of special relevance, if you're hoping to cut out a soda habit, the real addictive properties of refined sugar consumption that mirror that of more well-known drugs of abuse.
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Studies mentioned in podcast:
1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 10, 11, 14, 15, 16, 17, 18, 19
Today we try to answer or at least explore a big question in the world of health: does saturated fat cause heart disease?
This is not an unreasonable concern given the fact that there have been several associative studies that have found a link between saturated fat and heart disease, which is, no doubt, a fat that we find abundantly in the typical American diet since it is richly found in staples like fatty beef, pork, butter, cheese, and other dairy products.
And if you're in the United States and you're not at least a little concerned about heart disease, you may be asleep at the wheel since it's currently our leading cause of death.
Studies mentioned in this episode:
Genetics resources:
Does meat consumption cause cancer? Or, put another way… does avoiding meat help prevent cancer?
If you aren't already savvy to the topic, this may sound more absurd than it should. Here's why: there have been many, many, many correlative studies that have found that higher meat consumption is associated with a significantly higher risk of cancer and cancer mortality.
To try to answer this question we end up going deep into discussing plausible mechanisms that might help explain this phenomenon and, indeed, discussing a little bit of cancer biology as well.
Some of the publications mentioned in this podcast:
The World Health Organization estimates that more than 350 million individuals of all ages have depression and approximately one-third of all patients with depression fail to respond to conventional antidepressant therapies like SSRI’s.
The good news is that today, perhaps more than ever, good science is starting to illuminate some of the underlying biological mechanisms surrounding the development of depression. This new understanding may soon help the clinical world develop new approaches to treatment that may be vastly more effective and for a greater number of people than the traditional approaches.
Publications mentioned:
Antidepressants versus placebo in major depression: an overview
Inflammation: Depression Fans the Flames and Feasts on the Heat
Association of high-sensitivity C-reactive protein with de novo major depression.
Sex Differences in Depressive and Socioemotional Responses to an Inflammatory Challenge: Implications for Sex Differences in Depression
Dopaminergic Mechanisms of Reduced Basal Ganglia Responses to Hedonic Reward During Interferon Alfa Administration
Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward.
Structural and functional features of central nervous system lymphatic vessels
Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans
Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism
Neurobiology: Rise of resilience
First biological marker for major depression could enable better diagnosis, treatment
Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial
Sweetened-Beverages, Coffee, and Tea in Relation to Depression among Older US Adults (P05.122)
Consuming highly refined carbohydrates increases risk of depression
Dr. Roland R. Griffiths is a clinical pharmacologist at Johns Hopkins and has been researching mood-altering compounds for over 40 years. As an unusually prolific scientist, having published over 360-times, he's also responsible for having started the psilocybin research program at Johns Hopkins nearly 2 decades ago.
In this 1-hour and 15-minute podcast, we discuss…
Watch this as a video on YouTube.
Dr. Jed Fahey is a multi-decade veteran of isothiocyanate research and is the director of the Cullman Chemoprotection Center at Johns Hopkins University.
Much of this conversation, as you might expect given Dr. Fahey's pedigree as a research scientist, is focused on isothiocyanates and, indeed, sulforaphane!
While we covered quite a lot on this very topic (isothiocyanates) via my solo podcast a few weeks ago, this covers everything that may have been overlooked.... and, indeed, so much more! Skip to the timeline below for a sampling.
Dr. Fahey and his colleagues have been, in a big way, at the absolute center of what is a staggering amount of research on these very powerful compounds.
There is hardly a topic which we can discuss in which he doesn't have an anecdote about a study he was involved in, or, in some cases, tribal knowledge that may not even be published but is nonetheless interesting and an important part of the story that is unique to his particular vantage point.
In this 2-hour and 30-minute interview, we discuss...
You can find out more about Dr. Fahey and the Cullman Chemoprotection Center by visiting:
This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway.
The most potent naturally-occurring inducer of this pathway, a plant compound known as sulforaphane, may be one of the most potent health-enhancing compounds at our disposal and yet... no one is keeping it out of your hands! No $1,000 per pill markup is keeping it out of your hands -- it’s available to anyone willing to take the little bit of time it takes each week to produce broccoli sprouts.
In some respects, broccoli sprouts may even be a great equalizer in a way... while it’s true that healthy food can often be expensive, it’s even reasonably possible for a person to take $20 worth of seeds and feed their whole family some of the most healthful greens you could get your hands on. This video will tell you why.
Here are a few of the more salient points surrounding sulforaphane that are discussed in this podcast...
Key sections you may want to skip to:
00:03:35 - Cancer and mortality
00:21:56 - Aging
00:29:37 - Brain and behavior
00:41:33 - Final recap
00:44:18 - Dose
NOTE: If you enjoy this podcast, you'll enjoy the YouTube video more since it shows all of the figures and citations.