Marfan syndrome is a genetic disorder that makes renders the body’s connective tissues incredibly fragile; this can weaken the heart, leading to potentially fatal aneurysms. What’s more, anyone with the condition has a 50/50 chance of passing it on to their children.

Dr Anne Child is a clinical geneticist who’s dedicated her professional life to finding answers and solutions for people affected by Marfan’s.

Born in Canada, she met her British future-husband while working in Montreal in a case she describes as "love at first sight" - and in the 1970s she relocated her life to the UK.

There, an encounter with a Marfan patient she was unable to help set Anne on a career path for life. She subsequently established the team that discovered the gene responsible for Marfan's, and founded the Marfan Trust to drive further research. Since then, life expectancy for those with the condition has jumped from 32 years old, to over 70.

Speaking to Professor Jim Al-Khalili, Anne shares how she and her team achieved this remarkable turnaround.

Many of us have heard of seismology, the study of earthquakes; but what about asteroseismology, focusing on vibrations in stars?

Conny Aerts is a professor of Astrophysics at the University of Leuven in Belgium - and a champion of this information-rich field of celestial research. Her work has broken new ground in helping to improve our understanding of stars and their structures.

Conny describes herself as always being “something of an outlier” and she had to fight to follow her dream of working in astronomy. But that determination has paid off - today, Conny is involved in numerous interstellar studies collecting data from thousands of stars, and taking asteroseismology to a whole new level.

Recorded at the 2024 Cheltenham Science Festival, Prof Jim Al-Khalili talks to the pioneering Belgian astrophysicist about her lifelong passion for stars, supporting the next generation of scientists, and her determination to tread her own path.

When does a crowd of people become unsafe? How well will the football team Aston Villa do next season? When is it cost-effective to replace a kitchen? The answers may seem arbitrary but, to Nira Chamberlain, they lie in mathematics. You can use maths to model virtually anything.

A top secret little-known mission that changed the outcome of World War II. Not Alan Turing's Enigma code-breaking mission but a daring foray, conducted behind enemy lines on the shores of Normandy. Harrison Lewis and wetland scientist Christian Dunn re-enact one of the most remarkable feats of the Second World War and discover the intricate details of the daring but forgotten science that underpinned D-Day.