. . .y resembling paranucleins both in its properties and its C, H, and N content can be formed from the filtered products of the complete peptic hydrolysis of an approximately four per cent. neutral solu­tion of potassium caseinate by the action of pure pepsin at 36°C.

He considered this a case of a real synthesis of proteins from the products of its hydrolytic cleavage. This interpreta­tion was not generally accepted and received a different interpreta­tion by Bayliss and other workers. Gay and Robertson were able to show that paranuclein when injected into an animal will sensitize guinea-pigs for anaphylactic intoxica­tion for either paranuclein or casein and apparently indiscriminately. The products of complete peptic diges­tion of casein had no such effect, but the synthetic product of this diges­tion obtained by Robertson’s method has the same specific antigenic properties as paranuclein, thus making it appear that Robertson . . . Read More